Eudragit을 이용한 chlorhexidine함유 nanoparticle의 제조 및 용출에 관한 실험연구
An experimental study on the elution of the nanoparticle containing chlorhexidine
이광희, 김미정, 남용옥,
소속 상세정보
이광희 ( Lee Kwang-Hee ) - 원광보건대학교 치위생과
김미정 ( KIm Mi-Jung ) - 원광보건대학 치위생과
남용옥 ( Nam Yong-Ok ) - 원광보건대학교 치위생과
KMID : 0355419990230040409
Abstract
The purpose of this study was to manufacture nanoparticle containing chlorhexidine by using the Eudragit polymer, which are Eudragit RS, Eudragit RS/E, Eudragit RS/RL,
Eudragit RS/S, Eudragit RL, and Eudragit RL/E, and to evaluate the rate of elution of chlorhexidine.
The results were as follows:
1. Nanoparticles containing chlorhexidine were successfully manufactured by precipitation method.
2. These was no difference in the process of manufacture between nanoparticle containing chlorhexidine and blank nanoparticle.
3. After 60 minutes, the rate elution of standard chlorhexidine was about 90％, but that of nanoparticle containing chlorhexidine was about 60％. They showed statistically significant difference.
4. The rate of the elution was not greatly affected by the kind of polymer.
키워드
클로르헥시딘; Eudragit; 나노입자; 침전법;
Chlorhexidine; Eudragit; nanoparticle; precipitation method;
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